MDI may refer to:
- Major Depression Inventory, a self-report mood inventory developed by the World Health Organization
- Management Development Institute, a business school in Gurgaon, India
- Manual Data Input, a programming term which means that one or several humans feed a processing machine or computer with data from a control panel or keyboard.
- Metered dose inhaler, a device that helps deliver a specific amount of medication to the lungs
- Methylene diphenyl diisocyanate, a chemical
- Michelson Doppler Imager, an instrument on board the Solar and Heliospheric Observatory spacecraft.
- Micro finance Deposit-taking Institution, a company that provides micro loans or other micro finance services
- Motor Development International, a compressed air carmaker.
- Mount Desert Island, an island of the coast of Maine home to Acadia National Park.
- Movement for Democracy and Independence, was a political party in the Central African Republic
- Multiple Drug Intake an unnatural cause of death
In Computer Science
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