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According to the current Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), substance dependence is defined as:
Substance dependence can be diagnosed with physiological dependence, evidence of tolerance or withdrawal, or without physiological dependence.
The related concept of drug addiction has many different definitions. Some writers give in fact drug addiction the same meaning as substance dependence, others for example provides drug addiction a narrower meaning which excludes drugs without evidence of tolerance or withdrawal symptoms.
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